Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis.Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require substrate ubiquitination.Here, we characterize a key role for the UBE2G2 Binding Region (G2BR) of the E
Introduction: Local treatment of the airways and lung parenchyma has been used in clinical practice for several years for a variety of diseases.Methods: pet calming peanut butter A variety of endoscopic tools for local treatment exist, especially for treating malignancies.Using these endoscopic tools, one can administer drugs specifically designed
Objective: Prescription drug diversion, the transfer of prescription drugs from lawful to unlawful channels for distribution or use, is a problem in the United States.Despite the pervasiveness of diversion, there are gaps in the literature regarding characteristics of individuals who participate in the illicit trade of prescription drugs.This study
Background/Aims Despite the U.S.Food and Drug Adminstration approving a magnetic resonance imaging (MRI)-conditional pacemaker system in 2011, many physicians remain reluctant to perform MRI scanning in patients with cardiac implantable electronic devices.Herein, we aimed to evaluate the real-world safety of MRI in these patients.Methods This singl
In a future sustainable energy vision, in which diversified conversion of renewable energies is essential, vertical axis wind turbines (VAWTs) exhibit some potential as a reliable means of wind energy extraction alongside conventional horizontal axis wind turbines (HAWTs).Nevertheless, there is currently a relative shortage of scientific, academic